Nurse Directories on: The Nurse Friendly
Vasotec (enalapril maleate) ACE Inhibitors,
Hypertension Medications

See also: ACE Inhibitors, Cardiac, Coronary Heart Drugs, Hypertension

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Enalapril (Vasotec), Molecular Expressions:"Enalapril is a member of the Angiotensin-Converting Enzyme (ACE) inhibitors that is used to treat high blood pressure (antihypertensives). Enalapril itself is a "pro-drug" being converted in vivo into the active agent, enalaprilat that actually suppresses ACE. Side effects include dizziness, skin rash, confusion, and irregular heartbeat."
http://micro.magnet.fsu.edu/pharmaceuticals/pages/enalapril.html

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Enalapril Maleate:"Intravenous enalaprilat, or oral enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. The beneficial effects of enalapril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Although the latter decrease is small, it results in small increases of serum potassium. In hypertensive patients treated with enalapril alone for up to 48 weeks, mean increases in serum potassium of approximately 0.2 mEq/L were observed. In patients treated with enalapril plus a thiazide diuretic, there was essentially no change in serum potassium. (See PRECAUTIONS.) Removal of angiotensin II negative feedback on renin secretion leads to increased plasma renin activity."
http://www.rxlist.com/vasotec-drug.htm

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VASOTEC* (Enalapril Maleate):"Heart Failure: In trials in patients treated with digitalis and diuretics, treatment with enalapril resulted in decreased systemic vascular resistance, blood pressure, pulmonary capillary wedge pressure and heart size, and increased cardiac output and exercise tolerance. Heart rate was unchanged or slightly reduced, and mean ejection fraction was unchanged or increased. There was a beneficial effect on-severity of heart failure as measured by the New York Heart Association (NYHA) classification and on symptoms of dyspnea and fatigue. Hemodynamic effects were observed after the first dose, and appeared to be maintained in uncontrolled studies lasting as long as four months. Effect s on exercise tolerance, heart size, and severity and symptoms of heart failure were observed in placebo-controlled studies lasting from eight weeks to over one year."
http://www.druginfonet.com/vasotec.htm

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Some Popular Blood Pressure Medications Work Better than Others:
http://www.pslgroup.com/dg/DA02.htm

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Vasotec & Cholesterol, Med Help International:"My question, and sorry about so much detail, is both times that I have been put on relatively high doses of Vesotec by cholesterol has risen. Is there a correlation between this and the Vesotec."
http://www.medhelp.org/forums/cardio/archive/2594.html

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Send comments and mail to Andrew Lopez, RN

Created on Saturday, May 22, 1999

Last updated by Andrew Lopez, RN on Monday, November 22, 2010


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