Nursing & Healthcare Directories on: The Nursefriendly
Tetracyclic Antidepressants, Depression Medications
Mirtazapine, Remeron

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****************************************************** ****************************************************** Mirtazapine (Remeron) clinical pharmacology:rxlist:"The mechanism of action of REMERON® (mirtazapine) Tablets, as with other antidepressants, is unknown. Evidence gathered in preclinical studies suggests that mirtazapine enhances central noradrenergic and serotonergic activity. These studies have shown that mirtazapine acts as an antagonist at central presynaptic a2 adrenergic inhibitory autoreceptors and heteroreceptors, an action that is postulated to result in an increase in central noradrenergic and serotonergic activity. Mirtazapine is a potent antagonist of 5-HT2 and 5-HT3 receptors. Mirtazapine has no significant affinity for the 5-HT1A and 5-HT1B receptors. Mirtazapine is a potent antagonist of histamine (Hi) receptors, a property that may explain its prominent sedative effects. Mirtazapine is a moderate peripheral a1 adrenergic antagonist, a property that may explain the occasional orthostatic hypotension reported in association with its use. Mirtazapine is a moderate antagonist at muscarinic receptors, a property that may explain the relatively low incidence of anticholinergic side effects associated with its use." http://www.rxlist.com/cgi/generic/mirtaz_cp.htm ****************************************************** Possible drug interactions of Mirtazapine (Remeron):health-center:"Remember, always follow your physician's recommendations on how to take your medication. Also, if you are taking any herbal remedies, vitamins, and/or over-the-counter medications, be sure to tell your physician. The following section offers some, but not necessarily all, of the possible drug interactions. Do NOT take Remeron if you are taking MAOIs. Serious, even fatal, interactions have occured when these medications were combined. Allow 14 days between use of 2 drugs. Alcohol as well as Benzodiazepines (drugs like valium or diazepam) should also be avoided due to the additive motor skill impairment when taken with Remeron" http://www2.health-center.com/db/PageReq?SessionID=31107785.1037341881217&TopicID=377&PageID=1515&Action=view ****************************************************** Mirtazapine (Remeron) precautions:ahealthyme.com:"Tell your doctor your medical history, especially of: kidney problems, liver problems, other mental/mood conditions (e.g., bipolar disorder), seizures, heart disease, strokes, high cholesterol, any allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding." http://www.ahealthyme.com/viewmonograph?selectedDrugId=271090&selectedDrugDescription=Mirtazapine+Oral+Tablet+15+mg ****************************************************** Most important information to know about Mirtazapine (Remeron):drugs.com:"It may be several weeks before you start to feel better. Even when you start to feel better, do not stop taking mirtazapine without first talking to your doctor. Contact your doctor if you experience fever, chills, a sore throat, flu-like symptoms, or sores in the mouth or nose. Use caution when driving, operating machinery, or performing other hazardous activities. Mirtazapine may cause drowsiness and dizziness. If you experience drowsiness or dizziness, avoid these activities. Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. Avoid the use of alcohol while taking mirtazapine. Alcohol may increase drowsiness and dizziness. Mirtazapine is available in a regular tablet formulation (Remeron) that should be swallowed with water. Mirtazapine is also available in a rapidly-disintegrating formulation (Remeron SolTab) that will disintegrate rapidly when placed on the tongue and can be swallowed with or without water." http://www.drugs.com/xq/cfm/pageID_0/htm_d04025A1.htm/bn_Remeron/qx/index.htm ****************************************************** Mirtazapine (Remeron) special warnings:gettingwell.com:"Serious, sometimes fatal reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors, including the antidepressants Nardil and Parnate. Never take Remeron with one of these drugs or within 14 days of discontinuing therapy with one of them; and allow at least 14 days between stopping Remeron and starting an MAO inhibitor. If you develop "flu-like" symptoms, a sore throat, chills or fever, mouth sores, or any other signs of infection, call your doctor; these symptoms may signal a serious underlying condition. Remeron tends to raise cholesterol levels in some people. If you have a cholesterol problem, be sure to mention it to your doctor before starting therapy with Remeron. Remeron should be used with caution if you have active liver or kidney disease, or heart or blood pressure problems. Also be sure to tell your doctor if you have a history of seizures, mania (extremely high spirits), hypomania (mild excitability), drug use, or any other physical or emotional problems. While first taking this medication you may feel dizzy or light-headed, especially when getting up from a lying or sitting position. If getting up slowly doesn't help, or if this problem continues, notify your doctor. If you must avoid phenylalanine, do not use the SolTab form of Remeron, which contains this substance" http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/rem1371.shtml ****************************************************** Mirtazapine (Remeron) special information if you are pregnant or breastfeeding:healthsquare:"The effects of Remeron during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, tell your doctor immediately. It is not known whether Remeron appears in breast milk. However, because many drugs do make their way into breast milk, you should tell your doctor if you are breastfeeding or plan to breastfeed." http://www.healthsquare.com/newrx/rem1371.htm ****************************************************** Mirtazapine (Remeron) interactions with dietary supplements, food and other compounds:healthwell.com:"Interactions with Dietary Supplements Melatonin Taking mirtazapine results in enhanced secretion of melatonin at night;1 this may explain part of the mechanism of the effects of mirtazapine. Controlled research is needed to determine whether melatonin supplementation might enhance either the beneficial or the adverse effects of mirtazapine. Interactions with Foods and Other Compounds Alcohol Drinking alcoholic beverages while taking mirtazapine may enhance the effects of the drug, including impairment of thinking, judgment, and performance of difficult tasks; therefore, it should be avoided." http://www.healthwell.com/Healthnotes/Drug/Mirtazapine.cfm?path=hw ****************************************************** ****************************************************** Mirtazapine (Remeron) action and kinetics: Nursespdr:"Enhances central noradrenergic and serotonergic activity, perhaps by antagonism at central presynaptic alpha-2 adrenergic inhibitory autoreceptors and heteroreceptors. Also a potent antagonist of 5-HT2 5-HT3, and histamine H1 receptors. Moderate antagonist of peripheral alpha-1 adrenergic receptors and muscarinic receptors. Rapidly and completely absorbed from the GI tract. Peak plasma levels: Within 2 hr. t1/2: 20-40 hr. Extensively metabolized in the liver and excreted in both the urine (75%) and feces (15%). Females exhibit significantly longer elimination half-lives than males" http://www.nursespdr.com ****************************************************** ****************************************************** ****************************************************** ****************************************************** ****************************************************** Follow us on: Blogger: http://4nursing.blogspot.com Facebook: http://www.nursefriendly.com/facebook Linked In: http://www.linkedin.com/in/nursefriendly Nursing Entrepreneurs, Nurses In Business, http://nursingentrepreneurs.ning.com/ Twitter! http://www.nursefriendly.com/twitter StumbleUpon, http://www.nursefriendly.com/stumbleupon ****************************************************** If your website is not listed here, we encourage you to submit it: Add Your Website/URL. 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