Desipramine hydrochloride, American Medical Association:"Results In men, opioid abstinence was increased more rapidly over time when treated with methadone than with buprenorphine, whereas cocaine abstinence was increased more with buprenorphine than with methadone. In women, opioid abstinence was increased the least rapidly when treated with buprenorphine plus placebo, while cocaine abstinence was increased more rapidly over time when treated with methadone than with buprenorphine. Regardless of sex or opioid medication, desipramine increased opioid and cocaine abstinence more rapidly over time than placebo. Self-reported opioid use confirmed these findings. Desipramine plasma levels were higher in women than in men, particularly those on buprenorphine maintenance. Higher desipramine plasma levels were associated with greater opioid, but not cocaine, abstinence."
http://archpsyc.ama-assn.org/issues/v56n9/abs/yoa7361.html

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Desipramine hydrochloride, American Medical Association:"Background Studies show that selective serotonin reuptake inhibitors are effective for severe premenstrual syndrome and premenstrual dysphoric disorder. This study compares the efficacy of a selective serotonin reuptake inhibitor with that of a tricyclic antidepressant to determine whether efficacy for premenstrual syndrome/premenstrual dysphoric disorder is a general or more serotonergic effect of antidepressants. Methods After 3 screening months, 189 subjects were randomized to sertraline hydrochloride, desipramine hydrochloride, or placebo for 3 months of double-blind treatment. The flexible dosage range was 50 to 150 mg/d. The outcome measures included the Penn Daily Symptom Report (DSR), the Hamilton Depression Rating Scale, the Clinical Global Impressions–Severity Scale, the Quality of Life Scale, and Patient Global Ratings of Functioning and Improvement. Analyses included all subjects with treatment data, with the last observation carried forward."
http://archpsyc.ama-assn.org/issues/v56n10/abs/yoa9079.html

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Desipramine hydrochloride, At Health, Inc.:"Description: Norpramin (desipramine hydrochloride) is an antidepressant drug. Norpramin is classified as a tricyclic type antidepressant. Desipramine's chemical name is 5H-Dibenz(Bf)azepine-5-propanamine, 10,11- dihydro-N-methyl-, monohydrochloride. Indications: Norpramin (desipramine hydrochloride) is indicated for the treatment of depression. Usual Dosage: Although the dose for each patient may be individualized, the usual adult dose of desipramine is 100 to 200 mg per day."
http://www.athealth.com/Consumer/mcabinet/mcname_brand.cfm?brand=Norpramin

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Desipramine hydrochloride, CancerSource.com:"Lab Effects: Rarely, altered liver function studies. Rarely, increased or decreased serum glucose levels. Rarely, increased pancreatic enzymes. Rarely, bone marrow depression with agranulocytosis, eosinophilia, purpura, thrombocytopenia."
http://www.cancersourcemd.com/DrugDB/detail.cfm?DrugName=desipramine%20hydrochloride&ContentID=11951

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Desipramine hydrochloride, DepressionClinic.com:"Precautions: Not recommended for use in children. Precaution should be taken in patients with cardiovascular disease; history of urinary retention or glaucoma; history of seizures; history of mania. Monitor hyperthyroid patients or those receiving thyroid medication. Suicide is always a risk and precautions should be taken. Caution should be used when combining Norpramin with SSRIs, guanethidine or similar acting compounds, drugs metabolized by P450 2D6, anticholinergic drugs."
http://www1.depressionclinic.com/pharmacy/antidepressant/1587/tcas/pertofrane_des.htm

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Desipramine hydrochloride, MEDLINEplus:"Desipramine comes as a tablet to take by mouth. It is usually taken one or more times a day and may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take desipramine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take desipramine even if you feel well. Do not stop taking desipramine without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt."
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682387.html

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Desipramine hydrochloride, Internet Mental Health:"Overdose Symptoms: In patients presenting with signs of peripheral atropine effects, agitation and cardiac arrhythmias, the possibility of tricyclic antidepressant overdosage should be entertained. In view of the extensive tissue and protein binding of these drugs, blood and urine levels may not accurately reflect the extent of intoxication but may be helpful in identifying the presence of the drug."
http://www.mentalhealth.com/drug/p30-n03.html#Head_6

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Desipramine hydrochloride, Nurses's PDR Resource Center:"Uses: Symptoms of depression. Bulimia nervosa. To decrease craving and depression during cocaine withdrawal. To treat severe neurogenic pain. Cataplexy associated with narcolepsy. Attention deficit disorders with or without hyperactivity in children over 6 years of age. Contraindications: Use in children less than 12 years of age. Special Concerns: Safe use during pregnancy has not been established. Safety and efficacy have not been established in children."
http://www.nursespdr.com

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Desipramine hydrochloride, RxList:"Signs, Symptoms, and Laboratory Findings. Signs and symptoms of toxicity with tricyclic antidepressants most often involve the cardiovascular and central nervous systems. Overdosage with this class of drugs has resulted in death. Within a few hours of ingestion, the patient may become agitated, restless, confused, delirious or stuporous, and then comatose. Mydriasis, dry mucous membranes, vomiting, urinary retention, and diminished bowel sounds may occur. Hypotension, shock, respiratory depression, and renal shutdown may ensue. Generalized seizures, both early and later after ingestion, have been reported. Hyperactive reflexes, hyperpyrexia, and muscle rigidity can occur. EGG evidence of impaired conduction and serious disturbances of cardiac rate, rhythm, and output may occur. The duration of the OHS complex on EGG may be a helpful guide to the severity of tricyclic overdose, Physicians should be aware that relapses may occur after apparent recovery."
http://www.rxlist.com/cgi/generic2/desipram_od.htm

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Desipramine hydrochloride, WholeHealthMD.com:"Take it as prescribed for the full treatment period, even if you begin to feel better before the scheduled end of therapy. The decision to stop taking desipramine should be made in consultation with your doctor. The dosage should be tapered gradually over a period of 5 to 7 days when stopping treatment. Prolonged Use: Usual course of therapy lasts 6 months to 1 year; some patients may benefit from additional therapy."
http://www.wholehealthmd.com/refshelf/drugs_view/1,1524,177,00.html

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