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Antifibrinolytic Agents

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Drug class: Antifibrinolytic, antihemorrhagic (homepage)
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Amicar, Aminocaproic Acid, Antifibrinolytic Agents:"This medicine is an antihemorrhagic used to treat certain bleeding problems associated with surgery, blood disorders, and liver disease. It may also be used to treat other conditions as determined by your doctor."


Antifibrinolytic drugs for acute traumatic injury, Cochrane Database of Systematic Reviews:"Injury is an important cause of death. In many cases, death is due to uncontrolled bleeding. Antifibrinolytic drugs promote blood clotting by preventing the breakdown of blood clots and so can reduce blood loss. They are sometimes given to patients who are having surgery. This reduces blood loss and the need for blood transfusion. (This is important, as some infections can be transmitted through blood.) It is possible that these drugs might have similar benefits if given after injury in which case they could reduce death rates. This review looked for studies where antifibrinolytics have been used for this purpose. Only two small studies have taken place. They were small and the results were inconclusive. It is important that more research should be conducted."
John Wiley & Sons Inc
Subscription Department
111 River Street
Hoboken, NJ 07030
Toll-free USA only: 1 866 465 3817
Outside USA: 1 (201) 748 6645 Option 4
Fax: 1 (201) 784 5715


Antifibrinolytics for heavy menstrual bleeding (Cochrane Review):"Heavy menstrual bleeding (HMB) is an important cause of ill health in women. Medical therapy, with the avoidance of possibly unnecessary surgery, is an attractive treatment option. A wide variety of medications are available to reduce heavy menstrual bleeding but there is considerable variation in practice and uncertainty about the most appropriate therapy.Plasminogen activators are a group of enzymes that cause fibrinolysis (the dissolution of clots). An increase in the levels of plasminogen activators has been found in the endometrium of women with heavy menstrual bleeding compared to those with normal menstrual loss. Plasminogen activator inhibitors (antifibrinolytic agents) have therefore been promoted as a treatment for heavy menstrual bleeding."
John Wiley & Sons Inc
Subscription Department
111 River Street
Hoboken, NJ 07030
Toll-free USA only: 1 866 465 3817
Outside USA: 1 (201) 748 6645 Option 4
Fax: 1 (201) 784 5715


Antifibrinolytic Agents (Systemic), Before Using This Medicine,"In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For antifibrinolytic agents, the following should be considered: Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to aminocaproic acid or tranexamic acid. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. Pregnancy—Studies on birth defects have not been done in humans. However, these medicines have been given to pregnant women without causing birth defects or other problems. Studies on effects of aminocaproic acid in pregnancy have not been done in animals. Tranexamic acid has not been shown to cause birth defects or other problems in animal studies."
P.O. Box 302739 North Harbour Auckland, Auckland 1330 NZ


Antifibrinolytic agents for hemophilia, How It Works, Health"Antifibrinolytic agents may be used in specific situations or in combination with clotting factor replacement to treat hemophilia. Antifibrinolytic agents prevent the breakdown of blood clots by neutralizing chemicals in the mucous membranes of the mouth, nose, and urinary tract that break down clots."
Yahoo! Inc.
701 First Avenue
Sunnyvale, CA, 94089


Antifibrolytic Agents, Dosage & Usage Information,"How to take: Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food. Syrup--Take as directed on label. When to take: As directed by your doctor. If you forget a dose: Take as soon as you remember. Don't double this dose. What drug does: Inhibits activation of plasminogen to cause blood clots to disintegrate. Time lapse before drug works: Within 2 hours."
151 West Passaic Street
Rochelle Park, NJ 07662
Phone: (201) 767-4273
Fax: (201) 767-4194


Antifibrinolytic Agents (Systemic), Storage, Medicine Online Inc.:"To store this medicine: * Keep out of the reach of children. * Store away from heat and direct light. * Do not store the tablet form of this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down. * Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children."
Medicine Online Inc.
18800 Delaware Street, Suite 650
Huntington Beach, CA 92648-6017
Toll-free phone: (1-888) 666-5638
Phone: (1-714) 848-0444
Fax: (1-714) 841-6504


Antifibrinolytic Agents (Systemic), Medlineplus, National Library of Medicine:"Antifibrinolytic (an-tee-fye-bri-noh-LIT-ik ) agents are used to treat serious bleeding, especially when the bleeding occurs after dental surgery (particularly in patients with hemophilia) or certain other kinds of surgery. These medicines are also sometimes given before an operation to prevent serious bleeding in patients with medical problems that increase the chance of serious bleeding. Antifibrinolytic agents may also be used for other conditions as determined by your doctor. Antifibrinolytic agents are available only with your doctor's prescription, in the following dosage forms: * Oral Aminocaproic acid * Tranexamic acid."
National Library of Medicine
8600 Rockville Pike
Bethesda, Maryland 20894
Phone: (301) 496-6308 Fax: (301) 496-4450


Antifibrinolytic Agents in Traumatic Haemorrhage, PLoS Medicine:"This article is an invitation to doctors around the world to participate in the CRASH-2 trial (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage), a large, multi-centre, randomised controlled trial of a simple and widely practicable treatment for traumatic hemorrhage. The rationale for the trial and contact details for those who would like to take part are given below. Evidence from randomised controlled trials is essential for improving health care. In the case of widely practicable treatments for common health problems, even modest treatment effects can result in substantial health gains. However, to detect such modest effects requires large multi-centre randomised trials involving hundreds of collaborating health professionals internationally. Many health professionals would be pleased to collaborate in such trials if they knew that they were underway, but at present there is no easy way to bring these trials to their attention."
U.S. Headquarters
Public Library of Science
185 Berry Street, Suite 3100
San Francisco, CA 94107 USA
phone +1(415)624-1200
fax +1(415)546-4090


Antifibrinolytic agents for hemophilia, What To Think About, Saint Joseph Mercy Health System:"Antifibrinolytic medications: Help prevent bleeding in the mouth, nose, or urinary tract only. Can be used instead of clotting factor replacement after dental surgery. Can be taken in pill or liquid form and do not have to be injected (unlike clotting factors)."


Antifibrinolytic agents and desmopressin as hemostatic agents in cardiac surgery, The Annals of Pharmacotherapy: Vol. 35, No. 9, pp. 1075-1084.:"OBJECTIVE: To review the use of systemic hemostatic medications for reducing bleeding and transfusion requirements with cardiac surgery. DATA SOURCES: Articles were obtained through computerized searches involving MEDLINE (from 1966 to September 2000). Additionally, several textbooks containing information on the diagnosis and management of bleeding associated with cardiac surgery were reviewed. The bibliographies of retrieved publications and textbooks were reviewed for additional references. STUDY SELECTION: Due to the large number of randomized investigations involving systemic hemostatic medications for reducing bleeding associated with cardiac surgery, the article selection process focused on recent randomized controlled trials, metaanalyses and pharmacoeconomic evaluations."
Harvey Whitney Books Company
8044 Montgomery Road, Suite 415, Cincinnati, OH 45236-2919
P.O. Box 42696, Cincinnati, OH 45242-0696 USA
Tel. 513/793-3555, FAX 513/793-3600





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Last updated by Andrew Lopez, RN on Monday, January 31, 2011

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