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This page was prepared by Lynn Kash, RN, Internet Nursing Guide ******************************************************
AMYL NITRITE (Systemic), Description, Drugs.com:"Amyl nitrite (AM-il NYE-trite) is related to the nitrate medicines and is used by inhalation to relieve the pain of angina attacks. It works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload." ******************************************************
Amyl Nitrite, Smoke Inhalation & CO Poisoning Part II: Treatment, July 2002, Drug Category: Antidotes, Emergency Physicians Monthly:"Drug Name: Amyl nitrite-In the presence of nitrites, hemoglobin is converted to methemoglobin that has a higher binding affinity for cyanide than does the cytochrome oxidase complex. As a result, the electron transport and cellular respiration are able to continue, producing a methemoglobin level of 5%. This medication is given until an IV line is established and sodium nitrite can be administered. " ******************************************************
Amyl Nitrite, Description, Jeff's Pharmacology Review:"Amyl Nitrite is chemically related to nitroglycerin and has been used for many years to treat angina pectoris. It is also effective in the emergency management of cyanide poisoning by causing the oxidation of hemoglobin to the compound methemoglobin. Methemoglogbin reacts with the cyanide ion to form cyanomethemoglogin, which has less affinity for oxygen, thus freeing hemoglogin to react with oxygen." ******************************************************
AMYL NITRITE INHALANT, Uses, MdAdvice.com:"Treats angina pectoris attacks. Note: Don't use amyl nitrite expecting a "high" or as an aphrodisiac. Serious, harmful side effects may occur when Amyl Nitrite is abused." ******************************************************
Amyl Nitrite (Systemic), Description, MEDLINEplus:"Amyl nitrite (AM-il NYE-trite) is related to the nitrate medicines and is used by inhalation to relieve the pain of angina attacks. It works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload." ******************************************************
Amyl Nitrite, Action/Kinetics, Nurses PDR:" Believed to act by reducing systemic and PA pressure (afterload) and by decreasing CO due to peripheral vasodilation. Vascular relaxation occurs due to stimulation of intracellular cyclic guanosine monophosphate. As an antidote to cyanide poisoning, amyl nitrite promotes formation of methemoglobin which combines with cyanide to form the nontoxic cyanmethemoglobin. Onset (inhalation): 30 sec. Duration: 3-5 min. About 33% is excreted through the kidneys." ******************************************************
Amyl Nitrite, Indications, RXlist:"Amyl nitrite is indicated for the rapid relief of angina pectoris. Its effect appears within 30 seconds and lasts for approximately 3 to 5 minutes." ******************************************************
Amyl Nitrite, Description, Temple College:"Amyl Nitrite is chemically related to nitroglycerin and has been used for many years to treat angina pectoris. It is also effective in the emergency management of cyanide poisoning by causing the oxidation of hemoglobin to the compound methemoglobin. Methemoglogbin reacts with the cyanide ion to form cyanomethemoglogin, which has less affinity for oxygen, thus freeing hemoglogin to react with oxygen." ******************************************************
Amyl Nitrite, Range and Frequency, Whole Health Md:"No fixed schedule; take as needed. When angina attack occurs, break the protective cloth-covered glass capsule between your fingers and inhale one to six times while seated. If inhaling 2 capsules in 10 minutes does not bring relief, seek medical assistance immediately. When inhaling 2 capsules, wait three to five minutes between capsules." ******************************************************
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