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Antihypercalcemics, Chemotherapy Adjuvants,
Bone Resporption Inhibitors,
Zometa, Zoledronic Acid, Zolendronate

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Zolendronate, How Drug Works, American Cancer Society:"Zolendronate stops cancer cells from breaking down bone, thus stopping the calcium in the bone from going into the blood. It also seems to stop the cancer cells from growing in the bone, so it prevents new cancer spots in the bone. It may stop blood vessels from forming, so the cancer cells stop growing."
American Cancer Society
1599 Clifton Road, Atlanta, GA 30329
1-800-ACS-2345
http://www.cancer.org/

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Zoledronic Acid For Injection, How should I take it, DrugDigest.org:"This medication should only be given under the supervision of qualified medical personnel. The usual dose is 4 mg given as an intravenous infusion over a 15 minute period. For high calcium levels, usually one dose is given. Based on how high your calcium level is you may receive a repeat dose of this drug after 7 days."
Expresscripts.com
Burstyn, Lance
521 Alton Rd #208, Miami Beach, FL 33140, US
http://www.drugdigest.org/

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Zometa, Before using, Drugstore.com:"WARNING: This medicine may cause severe kidney problems or possibly kidney failure if given too quickly (over less than 15 minutes) or if the dose exceeds the recommended dose (4 mg). Give this medicine exactly as prescribed. Consult your doctor or pharmacist for additional information. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking another bisphosphonate. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITIONS may be needed if you are taking an aminoglycoside antibiotic. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED in children or if you have a severe kidney condition. Contact your doctor or pharmacist if you have any questions or concerns about this medicine."
DrugStore.com
407 Heron Drive, Swedesboro, NJ 08085-9810
1-800-378-4786
http://www.drugstore.com/

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Zoledronic Acid (Injection), If you miss a dose, Genesis Health System:"This medicine needs to be given on a fixed schedule. If you miss an appointment to receive your medicine, call your doctor or home health caregiver for instructions."
Genesis Health System
1227 E. Rusholme Street, Davenport, IA 52803
563-421-1000
http://www.genesishealth.com/

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Zoledronic Acid (Systemic), Other medical problems, Medformation.com:"The presence of other medical problems may affect the use of zoledronic acid. Make sure you tell your doctor if you have any other medical problems, especially: Previous allergic reaction to zoledronic acid or other drugs -May cause severe reaction. Asthma-Certain types of asthma may be worsened by zoledronic acid. Heart disease-May be worsened by zoledronic acid. Kidney disease-May be worsened by zoledronic acid."
Allina Health System
1375 Willow St, Minneapolis, MN 55403-2252 US
612 775 1253 fax: 612 775 1249
http://www.medformation.com/

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Zoledronic Acid (Systemic), Pregnancy, MEDLINEplus:"Zoledronic acid has not been studied in pregnant women. However, studies in animals have shown that zoledronic acid causes birth defects. Women of childbearing age should avoid becoming pregnant. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding- It is not known whether zoledronic acid passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children-Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of zoledronic acid in children with use in adults."
U.S. National Library of Medicine
8600 Rockville Pike, Bethesda, MD 20894
custserv@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/

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Zoledronic Acid--Injection, Side Effects, PersonalMd.com:"Nausea, vomiting, pain/redness/swelling at the injection site, or flu-like symptoms (e.g., fever, chills, muscle/joint aches or pains) may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: change in amount of urine, rash, itching, dizziness, lightheadedness, unusual weakness or tiredness, trouble sleeping, trouble breathing, burning or painful urination, mental/mood changes (e.g., agitation, anxiety, confusion). Tell your doctor immediately if any of these unlikely but serious side effects occur: chest pain, swelling of the legs or mouth, trouble swallowing, eye or vision problems (e.g., "pink eye"/conjunctivitis), persistent sore throat and fever, unusual bruising or bleeding. If you notice other effects not listed above, contact your doctor or pharmacist."
Personal MD
4725 First Street, Suite 275, Pleasanton, CA 94566
925 417 6840 - Phone, 925 600 7568 - Fax
http://www.personalmd.com/

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Zoledronic Acid, Indications, RxList.com:"Hypercalcemia of Malignancy: Zometa® (zoledronic acid) Injection is indicated for the treatment of hypercalcemia of malignancy.

Vigorous saline hydration, an integral part of hypercalcemia therapy, should be initiated promptly and an attempt should be made to restore the urine output to about 2 L/day throughout treatment. Mild or asymptomatic hypercalcemia may be treated with conservative measures (i.e., saline hydration, with or without loop diuretics). Patients should be hydrated adequately throughout the treatment, but overhydration, especially in those patients who have cardiac failure, must be avoided. Diuretic therapy should not be employed prior to correction of hypovolemia. The safety and efficacy of Zometa in the treatment of hypercalcemia associated with hyperparathyroidism or with other non-tumor-related conditions has not been established.

Multiple Myeloma and Bone Metastases of Solid Tumors: Zometa is indicated for the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. Prostate cancer should have progressed after treatment with at least one hormonal therapy."
RxList - The Internet Drug Index: Searchable drug database. RxList LLC
500 3rd Street Suite 530
San Francisco, CA 94107
707-747-0985 fax: 708 575 8638
info@rxlist.com
http://www.rxlist.com/

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Zoledronic Acid, What is the most important information I should know about zoledronic acid, Web Md Health:"Do not take zoledronic acid without first talking to your doctor if your have had an allergic reaction to zoledronic acid or another similar medication such as alendronate (Fosamax), etidronate (Didronel), pamidronate (Aredia), risedronate (Actonel), or tiludronate (Skelid)."
WebMD
1175 Peachtree Road, NE, Suite 2400, Atlanta, GA 30361.
212-624-3700service@webmd.net
http://my.webmd.com/content/drugs/

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Zoledronic Acid (Systemic), Proper Use of This Medicine, Yahoo Health:"Dosing - The dose of zoledronic acid will be different for different patients. Follow your doctor's orders. The following information includes only the average doses of zoledronic acid.

For intravenous dosage form: For treating multiple myeloma and bone metastases and, For treating hypercalcemia (too much calcium in the blood): Adults4 milligrams (mg) in a solution to be injected into a vein in not less than 15 minutes. ChildrenUse and dose must be determined by your doctor.

Your health care professional my also give you vitamins containing Vitamin D and calcium."
ale New Haven Health System
789 Howard Avenue, New Haven, CT 06519
Tel.(203)688-4608, Fax (203)688-3774
http://yalenewhavenhealth.org/

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Last updated by Andrew Lopez, RN on Monday, November 22, 2010


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