Hydrochlorothiazide, Indications, RXlist:"Hydrochlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Hydrochlorothiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Hydrochlorothiazide is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension."
http://www.rxlist.com/cgi/generic/hctz_ids.htm

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Hydrochlorothiazide, Description, MEDLINEplus:"High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Hydrochlorothiazide helps reduce the amount of salt and water in the body by acting on the kidneys to increase the flow of urine; this also helps to lower blood pressure."
Office of Communications and Public Liaison National Library of Medicine
8600 Rockville Pike Bethesda, Maryland 20894
Phone: (301) 496-6308 Fax: (301) 496-4450 email: publicinfo@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682571.html

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Hydrochlorothiazide, Action, Neonatology.org:"Inhibition of sodium reabsorption in the distal nephron. Increases urinary losses of sodium, potassium, magnesium, chloride, bicarbonate, and phosphorus. Decreases renal excretion of calcium. Inhibits pancreatic release of insulin. Displaces bilirubin from albumin."
http://www.neonatology.org/ref/meds/med51.html

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Hydrochlorothiazide, Warning, Mosby's Drug Consult:"USE IN PREGNANCY: When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, hydrochlorothiazide; lisinopril should be discontinued as soon as possible. See the WARNINGS section of the hydrochlorothiazide and lisinopril prescribing information."
http://www.mosbysdrugconsult.com/genrxfree/Top_200_2000/Drugs/E1458.htm

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Hydrochlorothiazide, Who is this for, Drug Digest:"Hydrochlorothiazide, a "water pill," is used to treat high blood pressure and fluid retention caused by various conditions, including heart disease. This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Hydrochlorothiazide also may be used to treat patients with diabetes insipidus and certain electrolyte disturbances and to prevent kidney stones in patients with high levels of calcium in their blood. Talk to your doctor about the possible risks of using this medicine for your condition."
http://www.drugdigest.org/DD/DVH/Uses/0,3915,325%7CHydrochlorothiazide,00.html

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Hydrochlorothiazide, Most important fact, WebMD.com:"To reduce nighttime urination, take hydrochlorothiazide and spironolactone before 6 p.m. and preferably in the morning. Take hydrochlorothiazide and spironolactone with food or milk to lessen stomach upset.Do not use salt substitutes or low-sodium milk products that contain potassium while taking hydrochlorothiazide and spironolactone. These products could cause very high levels of potassium in your blood. Ask your doctor or pharmacist about any salt substitutes you are taking.Use caution when driving, operating machinery, or performing other hazardous activities. Hydrochlorothiazide and spironolactone may cause dizziness. If you experience dizziness, avoid these activities."
http://my.webmd.com/drug_article/article/4046.1325?bn=Aldactazide

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Hydrochlorothazide, Thyazide diuretics, Health Well:"Thiazide diuretics are a family of drugs that removes water from the body. They are referred to as potassium-depleting because they cause the body to lose potassium as well as water. Potassium-depleting diuretics also cause the body to lose magnesium . Thiazide diuretics are used to lower blood pressure in people with high blood pressure are also used to reduce water accumulation caused by other diseases. Thiazide diuretics are also combined with other drugs to treat various conditions."
New Hope Natural Media
1401 Pearl Street
Boulder, CO 80302
303-939-8440
http://www.healthwell.com/healthnotes/healthnotes.cfm?ContentID=1517000

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Hydrochlorothiazide, Drug Interactioms, Asia Medicine Net:"Hydrochlorothiazide is eliminated rapidly by the kidneys and the dosage may have to be reduced in kidney dysfunction. It should be used with caution in patients with liver disease because of fluid and electrolyte problems. Patients allergic to sulfa may also be allergic to hydrochlorothiazide because of a similarity in the chemical structure of the medications. Hydrochlorothiazide can aggravate kidney dysfunction, and is used with caution in patients with kidney disease. Even though hydrochlorothiazide is important in treating excess fluid accumulation in patients with cirrhosis, loss of fluid and electrolytes in these patients can worsen kidney function and even cause the patient to go into a coma. Hydrochlorothiazide can cause lowering of blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to heart rhythm abnormalities, especially in patients already taking digoxin (Lanoxin). Please visit digoxin (Lanoxin) site for further information. Potassium supplementation is common during hydrochlorothiazide treatment."
http://www.asiamedicinenet.com/script/main/art.asp?li=AMN&ArticleKey=757

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Hydrochlorothiazide, Uses, Health Central:"ACE inhibitors combined with hydrochlorothiazide are used to treat high blood pressure . High blood pressure is treated with medication to prevent a stroke or damage to the heart and kidneys."
http://www.healthcentral.com/mhc/top/001900.cfm

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Hydrochlorothiazide, Description, Medizine:"This drug belongs to the thiazide group of diuretic drugs that remove excess water from the body and reduce oedema (fluid retention) in people with congestive heart failure, kidney disorders, cirrhosis of the liver and premenstrual syndrome. The drug is frequently used to treat high blood pressure and because it reduces the amount of calcium in the urine it may sometimes be used to prevent the recurrence of certain types of kidney stones. Hydrochlorothiazide increases the loss of potassium in the urine, which can cause a variety of symptoms and increases the likelihood of irregular heart rhythms, particularly if you are taking drugs such as digoxin. Potassium supplements are often prescribed with hydrochlorothiazide."
http://www.cix.co.uk/~cyberville/medizine/hydrochl.htm

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Last updated by Andrew Lopez, RN on Monday, November 22, 2010