This page was prepared by E.V. Stankowski, RN
http://onlinestudyprograms.com

US Brand Names: PREGNYL®, Chorex, Novarel, Profasi, Ovidrel, Human Chorionic Gonadotropin (hCG).
Canadian Brand Names: Pregnyl, Profasi HP
Generic Names: FSH / LH,
Chemical Name: CHORIONIC GONADOTROPIN (kor-ee-ON-ik goe-NAD-oh-troe-pin)
Drug Class: Infertility Agent

Pregnyl, What is HCG? Drugs.com:"Human chorionic gonadotropin (HCG) is a naturally occurring hormone produced by the placenta. HCG supports the normal development of an egg from the ovary and can induce ovulation. HCG also stimulates the production of androgens in men and progesterone in women. HCG is used to induce of ovulation (the release of an egg from the ovary) and to assist in getting pregnant. HCG is also used to stimulate the descent of undescended testicles in boys before puberty and to replace hormones in males with a pituitary deficiency. HCG may also be used for purposes other than those listed in this medication guide."
Hampstead Trust
ATTN: DRUGS.COM
c/o Network Solutions
P.O. Box 447
Herndon, VA 20172-0447
Phone: 570-708-8780
http://pregnyl.drugs.com

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Pregnyl, What if I miss a dose? Drugdigest.com: "Try not to miss a dose. If you are unable to keep an appointment to receive your dose, call your doctor to reschedule. For men or boys: If you are giving your own injections, and miss a dose, take it as soon as you remember. If you forget until the next day, skip the missed dose and continue with your schedule. Do not use double or extra doses. Call your prescriber if you have any questions.

For women receiving infertility treatments: It is important not to miss a dose, as the success of your fertility treatments depends on proper use of this medication, and fertility treatments are expensive. Call your prescriber or health care professional if you are unable to keep an appointment. If you are giving your own injections, do not use double or extra doses. Call your prescriber if you have any questions."
DrugDigest
Expresscripts.com
Burstyn, Lance
521 Alton Rd #208, Miami Beach, FL 33140, US
http://www.drugdigest.org/DD/DVH/Uses/0,3915,550290|Pregnyl,00.html

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Pregnyl, Who is this drug for? Drugstore.com:"This medicine is a hormone used to treat infertility in males and females. It may be used to treat other conditions as determined by your doctor."
13920 SE EASTGATE WAY STE 300
BELLEVUE, WA 98005-4440
US
Phone: (425) 372 3200
Fax:: (425) 881-8572
http://www.drugstore.com/pharmacy/prices/drugprice.asp?ndc=00052031510&trx=1Z5006

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Pregnyl, When To Not Use Pregnyl (Injection), Healthdigest.org:"You should not use this medicine if you have had an allergic reaction to chorionic gonadotropin (HCG), or if you have prostate cancer or similar kinds of cancer. A boy who has started puberty too soon (generally before age 9) should not use this medicine. You should not use this medicine if you are pregnant."
HealthDigest.org
210 Morgan Street
Raleigh, NC 27603
Phone:+1.8007829200
Email:info@healthdigest.org
http://www.healthdigest.org/Pregnyl-(Injection)_5769_PRO.php

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CHORIONIC GONADOTROPIN, How to Store and Dispose of This Medicine, Healthtouch.com: "Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets. This medicine comes as a powder that must be mixed with a special liquid before you can use it. If you store this medicine at home, keep the dry powder at room temperature, away from heat, moisture, and direct light. After mixing the powder with the liquid, keep the mixture in the refrigerator. Do not freeze. You can keep the mixtures of Pregnyl® and Novarel™ in the refrigerator for up to 60 days. You can keep the mixture of Profasi® in the refrigerator for up to 30 days. Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. You will also need to throw away old medicine after the expiration date has passed. Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid: Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products."
Health Touch.com
Cardinal Health, Inc.
7000 Cardinal Place
Dublin, Ohio 43017
US
Phone: 614-757-5014
Fax: 614-757-6014
http://www.healthtouch.com/bin/EContent_HT/dnoteShowLfts.asp?fname=04735&title=Pregnyl+%28Injection%29%2C+See+%7CCHORIONIC+GONADOTROPIN+%28Injection%29+%28Injectable%29+%7C+&cid=HTDRUG

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Chorionic Gonadotropin, Proper Use of This Medicine, Healthyahoo.com:"Dosing - The dose of chorionic gonadotropin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses for chorionic gonadotropin. If your dose is different, do not change it unless your doctor tells you to do so. The number of doses you receive each day, the time allowed between doses, and the length of time you receive the medicine depend on the medical problem for which you are receiving chorionic gonadotropin .

For injection dosage form: For treating men with problems related to low levels of male hormones: Adults1000 to 4000 Units injected into the muscle two to three times a week. You may need to receive this medicine for several weeks, months, or longer. If you are being treated for a low sperm count and have been on this medicine for six months, your doctor may give you another hormone medicine (menotropin or urofollitropin injection). You may need to receive both of these medicines together for up to twelve more months.

To help pregnancy occur in women: Adults5000 to 10,000 Units injected into the muscle on a day chosen by your doctor. The dose and day will depend on your hormone levels and the other medicines that you have been using.

For the treatment of cryptorchidism (condition where testes do not develop properly): Children1000 to 5000 Units injected into the muscle two to three times a week for up to ten doses. "
Health Yahoo.com
Yahoo! Inc.
(DOM-272993)
701 First Avenue
Sunnyvale, CA, 94089
US
http://health.yahoo.com/health/drug/202266/overview

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Chorionic Gonadotropin (Systemic), Action of this drug, Mayoclinic.com:"Chorionic gonadotropin (kor-ee-ON-ik goe-NAD-oh-troe-pin) is a drug whose actions are almost the same as those of luteinizing (loo-te-in-eye-ZING) hormone (LH), which is produced by the pituitary gland. It is a hormone also normally produced by the placenta in pregnancy. Chorionic gonadotropin has different uses for females and males.In females, chorionic gonadotropin is used to help conception occur. It is usually given in combination with other drugs such as menotropins and urofollitropin. Many women being treated with these drugs usually have already tried clomiphene alone (e.g., Serophene) and have not been able to conceive yet. Chorionic gonadotropin is also used inin vitrofertilization (IVF) programs.In males, LH and chorionic gonadotropin stimulate the testes to produce male hormones such as testosterone. Testosterone causes the enlargement of the penis and testes and the growth of pubic and underarm hair. It also increases the production of sperm.Although chorionic gonadotropin has been prescribed to help some patients lose weight, it should never be used this way. When used improperly, chorionic gonadotropin can cause serious problems.Chorionic gonadotropin is to be administered only by or under the immediate supervision of your doctor. It is available in the following dosage form: Parenteral Injection (U.S. and Canada)."
Mayo Foundation for Medical Education and Research
200 1st St. S.W.
Rochester, MN 55905
comments@mayoclinic.com
http://www.mayoclinic.com/invoke.cfm?objectid=63FF79A2-DA3A-4467-BE2938651BEEF18D

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Chorionic Gonadotropin, Side Effects of This Medicine, Medlineplus.com:"Along with its needed effects, a medicine may cause some other effects. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor as soon as possible if any of the following side effects occur: For females only: More common: Bloating (mild);  stomach or pelvic pain.   Less common or rare: Abdominal or stomach pain (severe);  bloating (moderate to severe);  decreased amount of urine;  feeling of indigestion;  nausea, vomiting, or diarrhea (continuing or severe);  pelvic pain (severe);  shortness of breath;  swelling of feet or lower legs;  weight gain (rapid) 

For boys only: Less common: Acne;  enlargement of penis and testes ; growth of pubic hair;  increase in height (rapid). 
Frequency not determined: difficult or labored breathing ;  difficulty breathing;  flushing of skin;  hives or welts;  itching of skin;  large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs;  pain in chest, groin, or legs, especially the calves;  redness of skin;  severe, sudden headache ;  skin rash;  slurred speech ;  sudden loss of coordination;  sudden, severe weakness or numbness in arm or leg;  sudden, unexplained shortness of breath;  tightness in chest;  unusually warm skin;  vision changes;  wheezing.  Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome: Less common: Discouragement;  enlargement of breasts ;  feeling sad or empty;  headache;  irritability;  lack of appetite;  loss of interest or pleasure;  pain at place of injection;  trouble concentrating;  trouble sleeping;  tiredness.
 
After you stop receiving this medicine, it may continue to cause some side effects which require medical attention. During this period of time check with your doctor if you notice any of the following side effects:
For females only: Less common or rare: Abdominal or stomach pain (severe);  bloating (moderate to severe);  decreased amount of urine;  feeling of indigestion;  nausea, vomiting, or diarrhea (continuing or severe);  pelvic pain (severe);  shortness of breath;  weight gain (rapid).  Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor."
National Library of Medicine
8600 Rockville Pike Bethesda, Maryland 20894
Phone: (301) 496-6308 Fax: (301) 496-4450
email: publicinfo@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202266.html

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Gonadotropins, including Ovidrel®, Pregnancy Considerations, Rxlist.com:"Pregnancy Category X. Fetal death and impaired parturition were observed in pregnant rats given a dose of choriogonadotropin alfa (25 mcg/day) equivalent to six times the maximum human dose of 250 mcg based on body surface area. Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised if hCG is administered to a nursing woman. Pediatric Patients: Safety and effectiveness in pediatric patients has not been established.Geriatric Patients: Safety and effectiveness in geriatric patients has not been established."       
RxList - The Internet Drug Index: Searchable drug database. RxList LLC
500 3rd Street Suite 530
San Francisco, CA 94107
707-747-0985 fax: 708 575 8638,info@rxlist.com
http://www.rxlist.com/cgi/generic/ovidrel_wcp.htm

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Human Chorionic Gonadotropin (hcg), What is the most important fact about this drug? Webmed.com:"Treatment with HCG increases the likelihood of multiple births. Multiple births carry additional risk both for the mother and for the babies.A small percentage of female patients treated with HCG have developed the ovarian hyperstimulation syndrome (OHSS), especially after the first cycle of therapy. Symptoms of OHSS include severe pelvic pain, swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, low urine output, diarrhea, and nausea or vomiting. OHSS can be fatal. Notify your doctor immediately or seek emergency medical attention if you develop any of these symptoms."
Web MD
669 River Drive
Center 2
Elmwood Park, NJ 07407
Phone: 201-703-3400
Fax: 201-703-3401
Sales Support: 1-877-GO-WEBMD
http://my.webmd.com/hw/drug_data/d00572a1.asp

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