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Examples of Immunomodulators include: azathioprine (AZA) (Imuran) 6-mercaptopurine (6-MP) (Purinethol) methotrexate (MTX) (Rheumatrex, Mexate) mycophenolate mofetil (CellCept) tacrolimus (Prograf)
See also: Immune Globulins, Interferons, Biological Response Modifiers
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Adalimumab, Humira, Rheumatoid Arthritis (RA), Tumor Necrosis Factor (TNF) Inhibitors: ******************************************************
Anakinra, Kineret, Rheumatoid Arthritis, Biological Response Modifiers, Prescription Drugs, Medications, Medicines ******************************************************
Azathioprine Sodium, Imuran, Rheumatoid Arthritis, Biological Response Modifiers, Prescription Drugs, Medications, Medicines ******************************************************
Copaxone, Glatiramer Acetate, Immunomodulators, Multiple Sclerosis MS Agents:"Glatiramer acetate is used in the treatment of the relapsing-remitting form of multiple sclerosis (MS). This medicine will not cure MS, but may extend the time between relapses." ******************************************************
Daclizumab, Zenapax, Immunosupressants, Organ Donation Rejection Agents, Monoclonal Antibodies:"Hoffman-La Roche's new monoclonal antibody drug, Zenapax (daclizumab), has been approved to prevent rejection of kidney transplants. The drug uses the body's own immune system to prevent the acute rejection that can make kidney transplants fail." ******************************************************
Enbrel, Etanercept, Immune Globulins, Biological Response Modifiers, Prescription Drugs, Medications ******************************************************
Etanercept, Enbrel, Immune Globulins, Biological Response Modifiers, Prescription Drugs, Medications ******************************************************
Glatiramer Acetate, Copaxone, Immunomodulators, Multiple Sclerosis MS Agents:"Glatiramer acetate is used in the treatment of the relapsing-remitting form of multiple sclerosis (MS). This medicine will not cure MS, but may extend the time between relapses." ******************************************************
Humira, Adalimumab, Rheumatoid Arthritis (RA), Tumor Necrosis Factor (TNF) Inhibitors: ******************************************************
Imuran, Azathioprine Sodium, Rheumatoid Arthritis, Biological Response Modifiers, Prescription Drugs, Medications, Medicines ******************************************************
Kineret, Anakinra, Rheumatoid Arthritis, Biological Response Modifiers, Prescription Drugs, Medications, Medicines ******************************************************
Zenapax, Daclizumab, Immunosupressants, Organ Donation Rejection Agents, Monoclonal Antibodies:"Hoffman-La Roche's new monoclonal antibody drug, Zenapax (daclizumab), has been approved to prevent rejection of kidney transplants. The drug uses the body's own immune system to prevent the acute rejection that can make kidney transplants fail." ****************************************************** ******************************************************
Topical Immunomodulators Prove Effective in Treating Eczema, Allergies @ About.com:"Topical Immunomodulators Prove Effective in Treating Eczema
For the estimated 15 million Americans with eczema -- a chronic skin disease in which the skin becomes itchy with red patches of inflamed skin -- finding effective, long-lasting treatments was a difficult and frustrating process. Now, two new non-steroidal medications recently approved by the U.S. Food and Drug Administration are improving the quality of life for eczema patients of all ages and offering hope as potential treatment options for patients with other hard-to-treat skin conditions." ******************************************************
Immunomodulatory Drugs, Multiple Myeloma Research Center, The Cleveland Clinic:"The IMiDs are a group of unique, orally bioavailable agents that have been refined using the parent IMiD compound, thalidomide, as a structural template. Modification of the thalidomide structure through the addition of an amino group at the 4 position of the phthaloyl ring forms CC-4047 (Actimid), and the removal of a carbonyl on the ring forms lenalidomide. They were specifically designed to enhance immunomodulation and anticancer properties but with less side effects. Immunomodulatory drugs have been shown to be 50,000 times more potent than thalidomide at inhibiting tumor necrosis factor–a (TNF-a ) from preclinical studies.1,2 Studies reveal that thalidomide and IMiDs not only inhibit angiogenesis but also induce apoptosis and growth arrest in resistant myeloma cells. They also prevent the adhesion of myeloma cells to bone marrow stromal cells and thereby inhibit the enhanced secretion of migratory factors, such as interleukin (IL)–6, TNF-a , and vascular endothelial growth factor.3-7 Lenalidomide has proven to have more potent activity than thalidomide in the preclinical setting.1,8 Another thalidomide analogue, CC-4047 (Actimid), also demonstrates potent activity against TNF-a and has recently entered clinical trials.9" ******************************************************
Understanding and Comparing Immunomodulators, Daiwa Pharmaceutical, Tokyo, Japan:"Immunomodulators are becoming very popular in the worldwide natural health industry as people start to realize the importance of a healthy immune system in the maintenance of health and the prevention and recovery of disease. Help the immune system, and the body helps itself — often quite considerably. However, there is a lot of misinformation circulating about these natural compounds, much of it put out by companies trying to sell their particular immunomodulator. There are even many doctors who are misinformed about the action of these compounds. Here we take a glance at immunomodulators and how to compare them." ******************************************************
Immunomodulators, OB/GYN News, Findarticles.com:"Several immunologic agents--adalimumab, anakinra, etanercept, three classes of interferons, and thalidomide--are classified in the general category of immunomodulators. They are used for various approved and offlabel indications: multiple sclerosis, rheumatoid arthritis, autoimmune disorders, and complications of leprosy, and for antitumor, antiviral, and antibacterial uses.
With the exception of thalidomide, these compounds are large molecules and may not reach the fetus. But their complex pharmacologic mechanisms may directly affect a number of maternal biologic processes, such as immune functions, response to infections and inflammation, cell proliferation, leukocyte migration, and prevention of cartilage degradation. Except for thalidomide, the human pregnancy experience with these agents is limited or completely lacking, making the decision about whether to use them during gestation problematic." ******************************************************
Immunomodulators and atopic dermatitis, Pediatrics for Parents, Findarticles.com:" The topical immunomodulators (a new class of drugs), pimecrolimus (Elidel) cream and tacrolimus (Protopic) ointment have been a boon to children with eczema (atopic dermatitis). Over 35 million children and adults are afflicted with this itchy dermatitis that has been likened to having poison ivy twenty four-hours a day.
This eczematous scourge with itching, redness, and oozing, plus sleepless nights for children and parents alike, has met its match many times with these two dermatologic products. Their advantages over topical steroids which, for the past half century, have been the mainstay of treatment for this allergic disorder, include lack of worry about thinning of the skin or stretch marks (striae). The concern about systemic absorption from topical application or the accentuation of infection has been greatly exaggerated." ******************************************************
Immunomodulators for inflammatory bowel disease, How It Works, Webmd.com:"Immunomodulator medications, such as azathioprine (AZA), 6-mercaptopurine (6-MP), methotrexate, and mycophenolate mofetil, weaken or suppress the immune system, which in turn decreases inflammation in the digestive tract. These medications are used most often to prevent the body from rejecting a newly transplanted organ, but they are also helpful in treating inflammatory bowel disease (IBD)."
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Last updated by Andrew Lopez, RN on Monday, November 22, 2010 |
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