Repronex, Repronex (menotropins) Who is this drug for? Drugdigest.org:"MENOTROPINS (Pergonal®, Humegon®, Repronex®), is a combination of two hormones, called follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Both of these hormones occur naturally in both men and women, and help with fertility. In men, these hormones can help stimulate the development of sperm. In women, these hormones stimulate the development of eggs within the ovary. To increase a woman's chance of getting pregnant, menotropins are used in combination with other fertility drugs. Menotropins are also used for in vitro fertilization ("test tube baby") programs. Menotropins are also known by the name "HMG". Generic menotropins injections are not yet available.

What should my health care professional know before I receive menotropins?
They need to know if you have any of these conditions:
•benign pituitary tumor
•cyst on the ovary
•ovarian failure
•testicular failure
•thyroid disease
•vaginal or unusual bleeding
•an unusual or allergic reaction to menotropins, other medicines, foods, dyes, or preservatives
•pregnant (this medicine should not be used if you are already pregnant)
•breast feeding"
DrugDigest
Expresscripts.com
Burstyn, Lance
521 Alton Rd #208, Miami Beach, FL 33140, US
http://www.drugdigest.org/
http://www.drugdigest.org/DD/DVH/Uses/0,3915,550288|Repronex,00.html

Repronex, Pregnancy & special instructions while on this drug, Drugstore.com:"KEEP ALL DOCTOR AND LABORATORY appointments while you are using this medicine. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. IF YOU EXPERIENCE difficulty breathing; tightness of chest; swelling of eyelids, face, or lips; or if you develop a rash or hives, tell your doctor immediately. Do not take any more doses of this medicine unless your doctor tells you to do so. USING THIS MEDICINE may result in multiple pregnancy (twins, etc.). Discuss this possibility with your doctor. DO NOT USE THIS MEDICINE if you are or become pregnant. IF YOU SUSPECT THAT YOU COULD BE PREGNANT, contact your doctor. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby."
drugstore.com, inc (22852362O)
13920 SE Eastgate Way, Suite 300
Bellevue, WA 98005
US
Phone: 999 999 9999
Fax: 999 999 9999
http://www.drugstore.com/pharmacy/prices/drugprice.asp?ndc=55566718502&trx=1Z5006

Repronex, Warnings and Precautions, Ferring Pharmaceuticals:"Repronex® is a drug that should only be used by physicians who are thoroughly familiar with infertility problems. It is a potent gonadotropic substance capable of causing mild to severe adverse reactions in women. Gonadotropin therapy requires a certain time commitment by physicians and supportive health professionals, and its use requires the availability of appropriate monitoring facilities (see PRECAUTIONS - Laboratory Tests). In female patients it must be used with a great deal of care.

Hypersensitivity/Anaphylactic Reactions
Hypersensitivity/anaphylactic reactions associated with menotropins administration have been reported in some patients. These reactions presented as generalized urticaria, facial edema, angioneurotic edema, and/or dyspnea suggestive of laryngeal edema. The relationship of these symptoms to uncharacterized urinary proteins is uncertain.
Ferring Pharmaceuticals, Inc.
400 Rella Boulevard
Suffern, NY 10901
Customer Service Line:1-888-FERRING
http://www.ferringusa.com/fertility_products/

Repronex, When not to use Repronex (Injection), Healthdigest.org:"You should not use this medicine if you have had an allergic reaction to menotropins, are pregnant or breastfeeding, or have unusual vaginal bleeding, thyroid disorders, cysts on the ovaries, enlarged ovaries, or primary testicular failure.

Proper Repronex (Injection) Storage
Store Repronex (Injection) at room temperature away from sunlight and moisture. Keep Repronex (Injection) and all medications out of the reach of children. "
HealthDigest.org
210 Morgan Street
Raleigh, NC 27603
Phone:+1.8007829200
Email:info@healthdigest.org
http://www.healthdigest.org/R-Tannic-S-A/Repronex-(Injection)_6139_PRO.php

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Menotropins, Most serious complication of this drug, IVFCenter.net:"The most common side-effect would be soreness and/or swelling at the injection site. However, Menotropins are potent drugs which can also cause serious side effects - most of which are related to potential hyperstimulation of the ovary. About 5-10% of women will develop mild to moderate uncomplicated ovarian enlargement, sometimes accompanied by abdominal swelling or abdominal pain. This condition will usually go away without treatment within two or three weeks.

Severe ovarian hyperstimulation is rare but about 0.5% of women on menotropin therapy will develop this more serious medical problem. Pronounced enlargement of the ovary, collection of fluid in the abdomen and lungs, low abdominal pain, and potential rupture of the ovary characterize severe hyperstimulation and may require hospitalization. Symptoms usually become evident about one week after the hCG injection. This condition is followed carefully with serial ultrasounds, blood work and a close monitoring of urinary output. Bed rest is important to prevent the above ovarian complications. Hospitalization is necessary in severe cases. Occasionally drawing fluid from the chest or abdominal cavity helps. Severe hyperstimulation is best managed by prevention i.e the hCG is withheld when there is a high risk of hyperstimulation."
Bedminster Medical Plaza
One Robertson Drive
Bedminster, NJ 07921
Tel: (908) 781-0666
Fax: (908) 781-6377
http://www.ivfcenter.net/Useful_Info/Scientific_Info/Menotropins.html

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Menotropins, Possible Side Effects, Mayoclinic.com:"Check with your doctor as soon as possible if any of the following side effects occur:
For females only
More common: Bloating (mild); pain, swelling, or irritation at place of injection; rash at place of injection or on body; stomach or pelvic pain. Less common or rare: Abdominal or stomach pain (severe); bloating (moderate to severe); decreased amount of urine; feeling of indigestion; nausea, vomiting, or diarrhea (continuing or severe); pelvic pain (severe); shortness of breath; swelling of the lower legs; weight gain (rapid).
For males only
More common: Dizziness; fainting; headache; irregular heartbeat; loss of appetite; more frequent nosebleeds; shortness of breath.
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if the following side effect continues or is bothersome:
Less common: Enlargement of breasts.

After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects: For females only: Abdominal or stomach pain (severe); bloating (moderate to severe); decreased amount of urine; feeling of indigestion; nausea, vomiting, or diarrhea (continuing or severe); pelvic pain (severe); shortness of breath; weight gain (rapid). Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Mayo Foundation for Medical Education and Research
200 1st St. S.W.
Rochester, MN 55905
comments@mayoclinic.com
http://www.mayoclinic.com/invoke.cfm?objectid=3EA8317F-DC67-4800-BE5455C2EDAB774A

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Menotropins, What does my medication look like?, Peacehealth.com:"Menotropins is available with a prescription under the brand names Pergonal and Humegon. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
Pergonal 75 IU powder for injection
Pergonal 150 IU powder for injection
Humegon 75 IU powder for injection
Humegon 150 IU powder for injection"
Healthwise, Incorporated
P.O. Box 1989
2601 N. Bogus Basin Road
Boise, Idaho 83701
1-800-706-9646
http://www.peacehealth.org/kbase/multum/d00571a1.htm

Repronex, Dosage and Adminsitration of drug, Rxlist.com:"Infertile patients with oligo-anovulation: The dose of Repronex® to stimulate development of ovarian follicles must be individualized for each patient. The lowest dose consistent with achieving good results based on clinical experience and reported clinical data should be used.

The recommended initial dose of Repronex® for patients who have received GnRH agonist or antagonist pituitary suppression is 150 IU daily for the first 5 days of treatment. Based on clinical monitoring (including serum estradiol levels and vaginal ultrasound results) subsequent dosing should be adjusted according to individual patient response. Adjustments in dose should not be made more frequently than once every 2 days and should not exceed more than 75 to 150 IU per adjustment. The maximum daily dose of Repronex® should not exceed 450 IU and dosing beyond 12 days is not recommended.

Administration: Dissolve the contents of one to 6 vials of Repronex® in one to two mL of sterile saline and ADMINISTER SUBCUTANEOUSLY OR INTRAMUSCULARLY immediately. Any unused reconstituted material should be discarded. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. The lower abdomen (alternating sides) should be used for subcutaneous administration."
RxList - The Internet Drug Index: Searchable drug database. RxList LLC
500 3rd Street Suite 530
San Francisco, CA 94107
707-747-0985 fax: 708 575 8638
info@rxlist.com
http://www.rxlist.com/cgi/generic/menotropins_ids.htm

Menotropins, If you miss a dose, Webmd.com:"Contact your doctor if you miss a dose of menotropins. Do not use a double dose of this medication without first talking to your doctor.

What happens if I overdose? An overdose of menotropins is unlikely to threaten life. Notify your doctor immediately or call an emergency room or poison control center for advice. Symptoms of a menotropins overdose are not known. Ovarian hyperstimulation syndrome (OHSS) may result with an overdose of menotropins. Symptoms of OHSS include swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, and nausea or vomiting. OHSS can be fatal.

What should I avoid while using menotropins? There are no restrictions on food, beverages, or activity during therapy with menotropins unless your doctor directs otherwise."
Web MD
669 River Drive
Center 2
Elmwood Park, NJ 07407
Phone: 201-703-3400
Fax: 201-703-3401
Sales Support: 1-877-GO-WEBMD
http://my.webmd.com/hw/drug_data/d00571a1?orgpath=/hw/drug_data/d00571a1

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