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Antihyperglycemic, Prescription Drugs, Medications, Medicines,
Metaglip, Glipizide/Metformin Hydrochloride

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This drug is also known as: Metaglip

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See also: NursingDiabetics.com for information on different types of Diabetes, Living with the Disease, Lifestyle Issues

Complete List of Diabetic Medications (oral and injectables)

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This page was prepared by Lynn Kash, RN, Internet Nursing Guide
Pennsylvania Nurses,Emergency Department
http://www.emergencyroomnursing.com/

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Metaglip, Who is this for, DrugDigest.org:"This product combines two drug ingredients-glipizide and metformin-to treat type 2 diabetes (formerly known as "non-insulin dependent" or "adult-onset" diabetes). Both glipizide (brand name: Glucotrol) and metformin (brand name: Glucophage) are available separately to treat diabetes. These two drugs are now also available combined into one product (brand name: Metaglip). Metaglip should be used along with proper diet and exercise to treat diabetes."
Expresscripts.com
Burstyn, Lance
521 Alton Rd #208, Miami Beach, FL 33140, US
http://www.drugdigest.org/

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, Metaglip, Possible side effects, Drugstore.com:"SIDE EFFECTS, that may go away during treatment, include metallic taste in mouth, nausea, vomiting, diarrhea, or stomach upset. If stomach symptoms recur later (after you are on the same dose for several days or more), tell your doctor immediately. A late recurrence of stomach symptoms may be due to lactic acidosis. (see Before Using This Medicine section). Headache, back pain, joint pain, weight gain, increased sensitivity to sunlight, cough or fever may also occur. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience unusual tiredness or weakness, trouble breathing, stomach pain, yellowing eyes or skin, dark urine, unusual bleeding or bruising, persistent sore throat or fever, unusual change in the amount of urine. This medication can cause low blood sugar (hypoglycemia). The symptoms include chills, cold sweat, dizziness, drowsiness, shaking, rapid heart rate, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you are in a situation where you don't have these reliable forms of glucose, eat a quick source of sugar such as table sugar, honey, or candy, or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level. Tell your doctor immediately about the reaction. To help prevent hypoglycemia, eat meals on a regular schedule and do not skip meals. Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor immediately. Your medication dosage may need to be increased. AN ALLERGIC REACTION TO THIS MEDICINE IS UNLIKELY, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist."
DrugStore.com
407 Heron Drive, Swedesboro, NJ 08085-9810
1-800-378-4786
http://www.drugstore.com/

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Glipizide and Metformin Hydrochloride, Indications, Routes and Dosages, eDruginfo.com:"First-line therapy, as adjunct to diet and exercise, to improve glycemic control in patients with type 2 diabetes--Adults: Initially, 2.5 mg/250 mg P.O. once daily with a meal. In patients whose fasting glucose is 280 to 320 mg/dl, start with 2.5 mg/500 mg P.O. b.i.d. Dosage may be increased in increments of one tablet per day q 2 weeks, up to a maximum of 10 mg/1,000 mg or 10 mg/2,000 mg daily in divided doses.

Second-line therapy in patients with type 2 diabetes when diet, exercise, and initial treatment with a sulfonylurea or metformin provides inadequate glycemic control--Adults: Initially, 2.5 mg/500 mg or 5 mg/500 mg P.O. b.i.d. with the morning and evening meals. Increase in increments of no more than 5 mg/500 mg, up to the minimum effective dose needed to adequately control glucose or to a maximum daily dose of 20 mg/2,000 mg."
Lippincott Williams & Wilkins
P.O. Box 1600, Hagerstown, MD 21741, USA.
In the US, dial 1 (800) 638-3030 http://www.lww.com/

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Glipizide/Metformin, Drugs and Foods to Avoid, Genesis Health System:"There are many other drugs that may interact with this medicine. Make sure your doctor knows about ALL other medicines you are using, especially insulin, Tagamet®, Compazine®, Coumadin®, Dilantin®, isoniazid, niacin, estrogens, birth control pills, thyroid medicine, diuretics or "water pills," heart or blood pressure medicine, steroids such as prednisone, medicine for yeast infections, or any cold or allergy medicines.

Do not drink alcohol while you are using this medicine."
Genesis Health System
1227 E. Rusholme Street, Davenport, IA 52803
563-421-1000
http://www.genesishealth.com/

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Glipizide and Metformin, What are the precautions when taking this medicine, HealthandAge.com:"Wear disease medical alert identification. Use caution if you are having surgery, if you have a heart attack, severe infection, or stroke, or if you are 80 years of age or older and have not had your kidney function tested. If you have lung disease, talk with healthcare provider. If you have a weakened heart, talk with healthcare provider. Do not drive if blood sugar has been low. There is a greater risk of an accident. Check medicines with healthcare provider. This medicine may not mix well with other medicines. Avoid alcohol (includes wine, beer, and liquor). Tell healthcare provider if you are pregnant or plan on getting pregnant. Tell healthcare provider if you are breast-feeding."
Norvartis
575 Eighth Avenue New York, NY 10018
US Phone: (212) 798 - 9107
http://www.healthandage.com/

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Metaglip, Most important fact about this drug, HealthSquare.com:"Metaglip could cause a very rare--but potentially fatal--side effect known as lactic acidosis. It is caused by a buildup of lactic acid in the blood. The problem is most likely to occur in people whose liver or kidneys are not working well, and in those who have multiple medical problems, take several medications, or have congestive heart failure. The risk also is higher if you are an older adult or drink alcohol. Lactic acidosis is a medical emergency that must be treated in a hospital. Notify your doctor immediately if you experience any of the following:

Symptoms of lactic acidosis may include: Dizziness, extreme weakness or tiredness, light-headedness, low blood pressure, low body temperature, slow or irregular heartbeat, rapid breathing or trouble breathing, sleepiness, unexpected or unusual stomach discomfort, unusual muscle pain."
New Media Systems, LLC
Jefferson Square Building 621 Shrewsbury Avenue Shrewsbury, NJ 07702
Phone (732) 212-9191 Fax (732) 212-1260
http://www.healthsquare.com/

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Glipizide and Metformin (Systemic), Pregnancy, MEDLINEplus:"Glipizide and metformin combination has not been studied in pregnant women or animals. However, independent studies with glipizide and also with metformin have not shown that either medicine causes birth defects or other problems in animal studies. It is easier during pregnancy to control your blood sugar by using injections of insulin rather than by taking oral diabetes medicines. Close control of your blood sugar can reduce the chance of your baby gaining too much weight, having birth defects, or having high blood sugar before birth. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding-It is not known whether glipizide or metformin passes into human breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children-Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of glipizide and metformin in children with use in other age groups."
U.S. National Library of Medicine
8600 Rockville Pike, Bethesda, MD 20894
custserv@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/

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Metaglip, Mechanism of Action, MosbysDrugConsult.com:"Metaglip combines glipizide and metformin HCl, two antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with Type 2 diabetes.

Glipizide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. Extrapancreatic effects may play a part in the mechanism of action of oral sulfonylurea hypoglycemic drugs. The mechanism by which glipizide lowers blood glucose during long-term administration has not been clearly established. In man, stimulation of insulin secretion by glipizide in response to a meal is undoubtedly of major importance. Fasting insulin levels are not elevated even on long-term glipizide administration, but the postprandial insulin response continues to be enhanced after at least 6 months of treatment.

Metformin HCl is an antihyperglycemic agent that improves glucose tolerance in patients with Type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin HCl decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization."
Elsevier, Health Sciences Division
11830 Westline Industrial Drive, St. Louis, MO 63146
1-800-545-2522 http://www.us.elsevierhealth.com/

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Glipzide/Metformin--Oral, Side Effects, PersonalMd.com:"Also see Warnings. Nausea, stomach upset, diarrhea, vomiting or metallic taste may occur initially as your body adjusts to the medication. If stomach symptoms recur later (after you are on the same dose for several days or more), tell your doctor immediately. A late recurrence of stomach symptoms may be due to lactic acidosis. Headache, back pain, joint pain, weight gain, increased sensitivity to sunlight, cough or fever may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual tiredness or weakness, trouble breathing. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: stomach pain, yellowing eyes or skin, dark urine, unusual bleeding or bruising, persistent sore throat or fever, unusual change in the amount of urine. This medication can cause low blood sugar (hypoglycemia). The symptoms include chills, cold sweat, dizziness, drowsiness, shaking, rapid heart rate, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you are in a situation where you don't have these reliable forms of glucose, eat a quick source of sugar such as table sugar, honey, or candy, or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level. Tell your doctor immediately about the reaction. To help prevent hypoglycemia, eat meals on a regular schedule and do not skip meals. Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor immediately. Your medication dosage may need to be increased. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist."
Personal MD
4725 First Street, Suite 275, Pleasanton, CA 94566
925 417 6840 - Phone, 925 600 7568 - Fax
http://www.personalmd.com/

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Glipizide and Metformin, What happens if I miss a dose, YaleNewHavenHealth.org:"Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication."
Yale New Haven Health System
789 Howard Avenue, New Haven, CT 06519
Tel.(203)688-4608, Fax (203)688-3774
http://yalenewhavenhealth.org/

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Last updated by Andrew Lopez, RN on Monday, November 22, 2010


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