This page was prepared by Lynn Kash, RN, Internet Nursing Guide
Pennsylvania Nurses,Emergency Department
http://www.nursefriendly.com/kash/

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Dornase Alfa, Who is this for, DrugDigest.org:"Dornase alfa is used to reduce the number of lung infections and to improve lung function in patients with cystic fibrosis. It breaks down the thick secretions in the airways, allowing air to flow better and preventing bacteria from building up. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information."
Expresscripts.com
Burstyn, Lance
521 Alton Rd #208, Miami Beach, FL 33140, US
http://www.drugdigest.org/

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Dornase Alfa, What is dornase alfa, Drugs.com:"Dornase alfa is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis. Dornase alfa is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections. Dornase alfa may also be used for purposes other than those listed in this medication guide."
Drugs.com
P.O. Box 302739, North Harbour, Auckland, Auckland 1330, NZ
http://www.drugs.com/

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Dornase Alfa (inhalation), Description, Medformation.com:"Dornase alfa (DOR-nayse AL-fa) is used in the management of cystic fibrosis. It is used every day with other cystic fibrosis medicines, especially antibiotics, bronchodilators (medicines that open up narrowed breathing passages), and corticosteroids (cortisone-like medicines).

Cystic fibrosis is a condition in which thick mucus is formed in the lungs and breathing passages. The mucus blocks the airways and increases the chance of lung infections. The infections then cause the mucus to become even thicker, making it more difficult to breathe.

Dornase alfa will not cure cystic fibrosis. However, when it is used every day, it helps make breathing easier and reduces the number of serious lung infections that require treatment with antibiotics."
Allina Health System
1375 Willow Street, Minneapolis, MN 55403,US
http://www.medformation.com/ac/mm_usp.nsf/usp/202710b.htm

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Dornase Alfa, Drug Class and Mechanism, MedicineNet.com:"Dornase alpha is an inhaled drug for treating the lung disease of cystic fibrosis, the most common fatal genetic disease in developed countries.

The lungs continually secrete fluid into the airways to keep them moist. In cystic fibrosis, the fluid becomes thick because the amount of water it contains is reduced. The thickened fluid is difficult to cough up or spit out. It blocks the airways, making breathing difficult and promoting the growth of bacteria and infection. Infection destroys the tissues of the lungs, and it is the slowly progressive destruction of the lungs that is the major cause of disability and death in children with cystic fibrosis. The thick fluid contains high concentrations of deoxyribonucleic acid (DNA). Dornase alpha is a genetically engineered form of the human enzyme, deoxyribonuclease or DNAse. Dornase alpha breaks down the DNA and thereby reduces the thickness of the fluids. Dornase alpha was approved by the FDA in 1993."
MedicineNet, Inc.
903 Calle Amanecer, Suite 300 San Clemente, CA 92673
Telephone: 949.940.6500 Fax: 949.940.1094, smartservice@medicinenet.com
http://www.medicinenet.com/

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Dornase Alfa, How should this medicine be used, MEDLINEplus:"Dornase alfa comes as a solution to inhale by mouth. It usually is taken one or two times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use dornase alfa exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Dornase alfa is used to treat cystic fibrosis but does not cure it. Continue to use dornase alfa even if you feel well. Do not stop using dornase alfa without talking to your doctor.

Before you use dornase alfa the first time, read the written instructions that come with it. Ask your doctor, pharmacist, or respiratory therapist to demonstrate the proper technique. Practice using the nebulizer while in his or her presence. Only use a nebulizer that is recommended by your doctor."
Office of Communications and Public Liaison
National Library of Medicine
8600 Rockville Pike Bethesda, Maryland 20894
Phone: (301) 496-6308 Fax: (301) 496-4450 email: publicinfo@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/

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PULMOZYME™, Action And Clinical Pharmacology, RxMed.com:"Dornase alfa for inhalation is a sterile, clear, colorless, highly purified solution of recombinant human deoxyribonuclease 1 (rhDNase), an enzyme which selectively cleaves DNA. The protein is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing DNA encoding for the native human protein, deoxyribonuclease 1 (Dnase). The product is purified by tangential flow filtration and column chromatography. The purified glycoprotein contains 260 amino acids with an approximate molecular weight of 37 000 daltons. The primary amino acid sequence is identical to that of the native human enzyme.

Pulmozyme is administered by inhalation of an aerosol mist produced by a compressed air driven nebulizer system (see Dosage)."
RxMed Inc.
1450, Kingston Rd, Suite 6B
Pickering, ONTARIO L1V1C1 CA
905-831-8240,
http://www.rxmed.com/b.main/b2.pharmaceutical/b2.prescribe.html

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Dornase Alfa, What storage conditions are needed for this medication, SafeMedication.com:"Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it in the refrigerator and protect it from sunlight. Do not expose the drug to room temperature for more than 24 hours. Any ampule that has been open for more than 24 hours should be discarded. Discard ampules if the solution is cloudy or discolored. Talk to your pharmacist about the proper disposal of medicine that is outdated or no longer needed."
American Society of Health-System Pharmacists
7272 Wisconsin Avenue Bethesda, MD 20814
301-657-3000
http://www.safemedication.com/

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Dornase Alfa (inhalation), What should I discuss with my healthcare provider before using dornase alfa, WebMd Health:"Do not use dornase alfa if you have had an allergic reaction to it or to other Chinese Hamster Ovary cell products.

Before using dornase alfa, tell your doctor if you have any other medical conditions or if you take other prescription or over-the-counter medicines. You may require a dosage adjustment or special monitoring during your treatment.

Dornase alfa is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment."
WebMD
1175 Peachtree Road, NE, Suite 2400, Atlanta, GA 30361.
212-624-3700service@webmd.net
http://my.webmd.com/content/drugs/

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Dornase Alfa, Range and Frequency, Whole Health MD:"Adults and children age 5 and older: 2.5 mg in a nebulizer once a day. Selected patients may require 2 daily doses. Use only the following nebulizers and compressors: Hudson T Up-draft II disposable jet nebulizer with the Pulmo-Aide compressor, Marquest Acorn II disposable jet nebulizer with the Pulmo-Aide compressor, or the PARI LC Jet+ nebulizer with the PARI PRONEB compressor."
WholeHealthMD LLC
11150 Sunset Hills Road, Suite 210, Reston, VA 20190.
http://www.wholehealthmd.com/

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